In the second day of the 2027 Africa Cup of Nations (CAN) qualifiers, Ghana and Nigeria suffered unexpected defeats. Guinea-Bissau defeated Nigeria 3-0 at home, while The Gambia upset Ghana 4-2 in Accra. The results highlight the competitive nature of the tournament, with underdogs emerging victorious.

The matches took place on September 29, 2024, as part of the group stage. Nigeria's loss to Guinea-Bissau came after a dominant performance by the West African nation, which controlled the game throughout. Ghana's defeat to The Gambia was equally surprising, with the latter scoring four goals in the second half. Both matches were played in different locations, with Guinea-Bissau hosting Nigeria and The Gambia welcoming Ghana.

This outcome marks a shift in the dynamics of the qualifiers, as traditional powerhouses face challenges from less-favored teams. The results may influence group standings and future match-ups, adding unpredictability to the tournament. The CAN 2027 qualifiers are set to continue with matches in Kenya, Tanzania, and Uganda.